CD3-HM433F-100μg / 询价
CD3-HM433F-500μg / 询价
CD3-HM433F-500μgx2 / 询价
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FITC-Labeled Human Siglec-3/CD33 Protein
Recombinant FITC-Labeled Human Siglec-3/CD33 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Asp18-His259 [Accession | P20138-1].
The protein has a predicted MW of 29.6 kDa. Due to glycosylation, the protein migrates to 48-58 kDa based on Bis-Tris PAGE result.
Excitation Wavelength: 490 nm
Emission Wavelength: 520 nm
> 95% as determined by Bis-Tris PAGE
Less than 1 EU per μg by the LAL method.
Supplied as 0.22μm filtered solution in 10mM NaH2PO4, 2mM EDTA, 500mM NaCl (pH 7.4).
Valid for 6 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
FITC-Labeled Human Siglec-3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
CD33 (siglec-3), a well-known target in leukemia therapy, is an inhibitory sialoadhesin expressed in human leukocytes of the myeloid lineage and some lymphoid subsets, including NK cells. CD33 is the smallest siglec member. It preferentially binds to α2-6- and α2-3-sialylated glycans and strongly binds to sialylated ligands on leukemic cell lines.
CD33 molecule; CD33; FLJ00391; gp67; Siglec3; Siglec-3; p67
Hernández-Caselles T, Miguel RC, Ruiz-Alcaraz AJ, García-Peñarrubia P. CD33 (Siglec-3) Inhibitory Function: Role in the NKG2D/DAP10 Activating Pathway. J Immunol Res. 2019 Apr 15;2019:6032141. doi: 10.1155/2019/6032141. PMID: 31143782; PMCID: PMC6501159.
