CD3-HM433F-100μg / 询价
CD3-HM433F-500μg / 询价
CD3-HM433F-500μgx2 / 询价
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FITC-Labeled Human Siglec-3/CD33 Protein
Recombinant FITC-Labeled Human Siglec-3/CD33 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Asp18-His259 [Accession | P20138-1].
The protein has a predicted MW of 29.6 kDa. Due to glycosylation, the protein migrates to 48-58 kDa based on Bis-Tris PAGE result.
Excitation Wavelength: 490 nm
Emission Wavelength: 520 nm
> 95% as determined by Bis-Tris PAGE
Less than 1EU per μg by the LAL method.
Supplied as 0.22μm filtered solution in 10mM NaH2PO4, 2mM EDTA, 500mM NaCl (pH 7.4).
Valid for 12 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
FITC-Labeled Human Siglec-3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state.They are sialoadhesin/CD169/Siglec-1, CD22/Siglec-2, CD33/Siglec-3, Myelin-Associated Glycoprotein (MAG/Siglec-4a) and Siglecs 5 to 11. To date, no Siglec has been shown to recognized any cell surface ligand other than sialic acids, suggesting that interactions with glycans containing this carbohydrate are important in mediating the biological functions of Siglecs.
CD33 molecule; CD33; FLJ00391; gp67; Siglec3; Siglec-3; p67
(1)Walter R B , Appelbaum F R , Estey E H , et al. Acute myeloid leukemia stem cells and CD33-targeted immunotherapy[J]. Blood, 2012, 119(26):6198-6208.
